Publications and Files

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Publications (* denotes University of Richmond Undergraduate)

• M. Rajeev* C.C. Helms. “A Study of the Relationship between Polymer Solution Entanglement and Electrospun PCL Fiber Mechanics.” Polymers 2023.15(4555). doi:10.3390/polym15234555
• N., Rimi* C.C. Helms. "Labeling fibrin fibers with beads alters single fibrin fiber lysis, external clot lysis, and produces large fibrin aggregates upon lysis." Blood Coagulation & Fibrinolysis. 2022.33(7). doi: 10.1097/MBC.0000000000001150
• C. Fryer*, M. Scharnagl*, C.C. Helms. "Electrostatic alignment of electrospun PEO fibers by the gap method increases individual fiber modulus in comparison to non-aligned fibers of similar diameter." AIP Advances. 2018.8(6). doi:10.1063/1.5027812
• C.C. Helms, M.T. Gladwin, D.B Kim-Shapiro. Erythrocytes and Vascular Function: Oxygen and Nitric Oxide. Frontiers in Physiology. 2018.9:125. doi: 10.3389/fphys.2018.00125
• W. Li, J. Sigley, S. Baker,C.C. Helms, M. Kinney, M. Pieters, P. Brubaker, R. Cubcciotti, M. Guthold. Non-uniform internal structure of fibrin fibers: Protein density and bond density strongly decrease with increasing diameter. BioMed Research International. 2017 doi: 10.1155/2017/6385628
• C.C. Helms, S. Kapadia*, A.C. Gilmore*, Z. Lu*, S. Basu, D.B. Kim-Shapiro.Exposure of fibrin and thrombin to nitric oxide donor ProliNONOate affects fibrin clot properties. Blood Coagulation and Fibrinolysis. 2017.28(5):356-364. doi: 10.1097/MBC
• C.C. Helms, X. Liu, D.B Kim-Shapiro. Recent insights into nitrite signaling processes in blood. Biological Chemistry. 2017.398(3):319-329
• W. Li, J. Sigley, M. Pieters, C.C. Helms, C. Nagaswami, J. W. Weisel, M. Guthold. Fibrin Fiber Stiffness Is Strongly Affected by Fiber Diameter, but not by Fibrinogen Glycation. Biophysical Journal. 2016.110(6):1400-1410.
• C. Liu, N. Wajih, X. Liu, S. Basu, J. Janes, M. Marvel, C. Keggi, C.C. Helms, A.N. Lee, A.M. Belanger, D.I. Diz, P.J. Laurienti, D.L. Caudell, J. Wang, M.T. Gladwin, D.B. Kim-Shapiro. Mechanisms of Human Erythrocytic Bioactivation of Nitrite. Journal of Biological Chemistry. 2015.290(2):1281-94.
• M.J. Berry, N.W. Justus, J.I. Hauser, A.H. Case, C.C. Helms, S. Basu, Z. Rogers, M.T. Lewis, G.D. Miller. Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide. 2014.48(1):22-30.
• K. Kemper, D. Powell, C.C. Helms, D.B. Kim-Shapiro. Loving-kindness meditation's effects on nitric oxide and perceived well-being: A pilot study in experienced and inexperienced meditators. Explore: The Journal of Science and Healing. 2014.11:32-39.
• D. Wang, I. Cortes-Puch, J. Sun, S.B. Solomon , T. Kanias, K. Remy, J. Feng, M. Alimchandani, M. Quezado,C.C. Helms, A. Perlegas, M.T. Gladwin, D.B. Kim-Shapiro, H. Klein, C. Natanson. Transfusions of older stored blood worsens outcomes in canines depending on the presence and severity of pneumonia. Transfusion. 2014.54(7):1712-1724.
• C.C. Helms, M. Marvel, W. Zhao, M. Stahle, R. Vest, G.J. Kato, J.S. Lee, G. Christ, M.T. Gladwin, R.R. Hantgan, D.B. Kim-Shapiro. Mechanisms of hemolysis-associated platelet activation. Journal of Thrombosis and Haemostasis. 2013.11(12):2148-2154.
• C.C. Helms and D. Kim-Shapiro. Hemoglobin-mediated nitric oxide signaling. Free Radic Biol Med. 2013. 61:464-472
• S.B. Solomon, D. Wang, J. Sun, T. Kanias, J. Feng, C.C. Helms, M.A. Solomon, M. Alimchandani, M. Quezado, M.T. Gladwin, D.B. Kim-Shapiro, H.G. Klein, C. Natanson. Mortality increases after massive exchange transfusion with older stored blood in canines with experimental pneumonia. Blood. 2013.121(9):1663-1672.
• D. Wang, B. Piknova, S.B. Solomon, I. Cortes-Puch, S.J. Kern, J. Sun, T. Kanias, M.T. Gladwin,C.C. Helms, D.B. Kim-Shapiro, A.N. Schechter, C. Natanson. In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion. 2013. 53(12):3149-63
• S.B. Solomon, L. Bellavia, D. Sweeney, B. Piknova, A. Perlegas,C.C. Helms, G.A. Ferreyra, S.B. King, N.J.H. Raat, S.J.Kern, J. Sun, L. Mcphail, A.N. Schechter, C. Natanson, M.T. Gladwin, D.B. Kim-Shapiro. Angeli's Salt Counteracts the Vasoactive Effects of Elevated Plasma Hemoglobin. Free Radic Biol Med. 2012.53(12):2229-2239.
• R.D. Averett, B. Menn, E.H. Lee,C.C. Helms, T. Baker, M. Guthold. A modular fibrinogen model that captures the stress-strain behavior of fibrin fibers. Biophysics Journal. 2012. 103(7):1537-44.
• J. Tejero, S. Basu,C.C. Helms, N. Hogg, S.B. King, D.B. Kim-Shapiro, M.T. Gladwin. Low NO concentration dependence of the reductive nitrosylation reaction of hemoglobin. Journal of Biological Chemistry. 2012. 287(22):18262-74
• G. Miller, A. Marsh, R.W. Dove, D. Beavers, T. Presley,C.C. Helms, E. Bechtold, S.B. King, D. Kim-Shapiro. Plasma nitrate and nitrite are increased by a high nitrate supplement, but not by high nitrate foods in older adults. Nutrition Research. 2012. 32(3):160-8.
• C.C. Helms, R. Ariens, S. Uitte de Willige, K. Standeven, M. Guthold. Alpha-alpha Cross-Links Increase Fibrin Fiber Elasticity and Stiffness. Biophysical Journal. 2012. 102(1):168-175.
• S. Baker, J. Sigley,C. Carlisle, J. Stitzel, J. Berry, M. Guthold. The mechanical properties of dry, electrospun fibrinogen fibers. Materials Science and Engineering C. 2011. 32: 215-221
• J. Kim, H. Song, I. Park,C. Carlisle, K. Bonin, M. Guthold. Denaturing of single electrospun fibrinogen fibers studied by deep ultraviolet fluorescence microscopy. Microscopy Research and Technique. 2011. 74(3): 219-224.
• W. Liu,C.R. Carlisle, E.A. Sparks, M. Guthold. The mechanical properties of single fibrin fibers. Journal of Thrombosis and Haemostasis. 2010. 8(5): 1030-1036(co-first author)
• C.R. Carlisle, E.A. Sparks, C. Der Loughiam, M. Guthold. Strength and Failure of Fibrin Fiber Branch Points. Journal of Thrombosis and Haemostasis. 2010. 8(5): 1135-1138.
• C.R. Carlisle, C. Coulais, M. Guthold. The mechanical stress-strain properties of single electrospun collagen type I nanofibers. Acta Biomaterialia. 2010. 6(8): 2997-3003.
• C.R. Carlisle, C. Coulais, M. Namboothiry, D. Carroll, R.R. Hantgan, M. Guthold. The mechanical properties of individual, electrospun fibrinogen fibers. Biomaterials. 2009. 30(6): 1205-1213.